Debraj GuhaThakurta's Page
Debraj's Personal Web Page
Brief C.V.
Specialties
- Bioinformatics, computational biology, genomics, genetics, molecular profiling, microarray, pharmacogenomics (PGx).
- Genomic as well as clinical data integration and mining for supporting all aspects of R&D pipeline for specific therapeutic areas (early discovery, diagnostics and late stage development).
- Target and biomarker discovery through integrative mining of large-scale genetic and genomic data from clinical and pre-clinical populations.
SUMMARY
• 10 years of experience in computational biology, genomics and genetics; 7 years of experience in the biopharmaceutical discovery setting.
• Extensive experience in computational data analysis, integration and mining of large-scale genomic, genetic and clinical data-sets.
• Extensive experience in gene and disease pathway discovery using computational biology, genetics and microarray.
• Human genetic studies for disease and pharmacogenetic biomarker identification
• Direct supervision of Ph.D. and masters level researchers. Supervision of efforts of personnel in matrixed work environments
BROAD INTERESTS
Application of bioinformatics and genomic technologies towards target and biomarker discovery. Disease risk and patient segmentation for therapies in clinical development.
PROFESSIONAL SERVICES
• Reviewer for many journals (Nature Biotech, Nat Protocols, Genome Research, Genomics, Bioinformatics, NAR, PLoS Comp. Biol., etc.) and for national and international research grant applications (including NIH, NSF).
• Associate editor for special journal issues on computational biology.
• Moderator, advisory council member, committee member for conferences.
Work experience
BIOINFORMATICS/GENOMICS RESEARCHER
(Public Company; 10,001 or more employees; GNE; Biotechnology industry)
March 2009 – Present
- Discovery of molecular diagnostic markers (gene expression, CNVs, mutations) for oncology therapies.
RESEARCH FELLOW, ROSETTA INPHARMATICS/MERCK & CO.
(Public Company; 10,001 or more employees; MRK; Pharmaceuticals industry)
March 2006 – March 2009 (3 years)
- R&D portfolio support (early to late stage clinical) for therapeutic areas through the application of bioinformatics, genetics and genomic methods.
- Identification of novel drug targets and biomarkers (disease risk as well as patient segmentation) through the integration of genomics and genetics approaches in pre-clinical and clinical samples.
Sr. Research Scientist at Rosetta Inpharmatics/ Merck & Co.
(Public Company; 10,001 or more employees; MRK; Pharmaceuticals industry)
October 2003 – February 2006 (2 years 5 months)
- Using integrated genotype, clinical endpont and microarray profiling approaches to identify new drug targets for complex human diseases, primarily atherosclerosis and hypertension.
- Functional annotation of human genomes using sequence mapping and microarray expression analysis.
- Transcriptional regulatory networks and regulatory polymorphism identification.
Genome Analyst at Rosetta Inpharmatics/Merck & Co.
(Public Company; 10,001 or more employees; MRK; Pharmaceuticals industry)
January 2002 – September 2003 (1 year 9 months)
- Functional annotation of human genomes using sequence and microarray expression analysis.
- Identification of novel genes and other expressed sequences in the human genome through sequence mapping, exon and tiling arrays.
- Results at: http://genomebiology.com/2004/5/10/R73
Postdoctoral Fellow at Washington University School of Medicine
(Educational Institution; 201-500 employees; Research industry)
July 1999 – December 2001 (2 years 4 months)
- Computational biology, algorithm development for genome sequence analysis
- Computational and experimental analysis of transcription regulatory sequences
Ph.D. Student & Research Assistant at Johns Hopkins University
(Educational Institution; 10,001 or more employees; Higher Education industry)
July 1995 – July 1999 (4 years 1 month)
- Characterization of the recognition between ribosomal protein L11 and ribosomal RNA using biophysical and molecular biology approaches.
- Discovery of molecular diagnostic markers (gene expression, CNVs, mutations) for oncology therapies.
EDUCATIONAL HISTORY
Washington University in St. Louis School of Medicine
Postdoctoral, Computational Biology, 1999 – 2001
Advisor: Dr. Gary D. Stormo
Joseph Erlanger Professor of Genetics and Biomedical Engineering, and Director of the Computational Biology ProgramThe Johns Hopkins University
Ph.D., Biophysical Chemistry, 1994 – 1999
Ph.D. Thesis: Characterization of L11-rRNA recognition in the ribosome.
Advisor: Dr. David E. Draper, Vernon K. Krieble Professor
Departments of Chemistry, Biology and BiophysicsIndian Institute of Technology, Kanpur, india
MS, Chemistry, 1992 – 1994
Thesis in organometalic approaches for oxidation of organic compounds.
Advisor: Dr. Javed Iqbalpresidency college, university of calcutta, india
BS, Chemistry, 1989 – 1992
Honors in Chemistry. Ranked first in graduating class in Chemistry.
Debraj's Personal Web Page
