CURRENT RESEARCH: 

• Discovery of novel therapeutic targets and diagnostic biomarkers for patient segmentation to oncology and cardiovascular therapies.

• Computational biology, genomics and genetics applications towards problems in biopharmaceutical R&D.

• Analysis of large-scale molecular profiling data and genetic data (microarray, GWAS, CNV) in pre-clinical and clinical population for identification of new targets and diagnostic markers for patient segmentation.

• Transcriptional regulatory networks. Idenfification of disease associated pathways. Computational approaches towards annotation of functional DNA variants.

• Database development and integration of genomic, genetic and profiling information.

• DNA pattern recognition and computational analyses of transcription regulatory elements in eukaryotic genomes

PAST RESEARCH:

• RNA-protein recognition in the ribosomes; study of L11-rRNA using mutational and biophysical approaches

COLLABORATORS:

• Eric Schadt (Pacific Biosciences)
  
• Stephen Edwards (US-EPA)
  
• Gary D. Stormo (Washington U. School of Med., St. Louis)
• David E. Draper (Johns Hopkins U., Baltimore)
  
• Bob Waterston (U. Washington, Seattle)
  
• Linda Breeden (Fred Hutchinson Cancer Research Center, Seattle)
• Christopher Link (U. Colorado, Boulder)
• Jim McGhee (U. Calgary, Canada)
• A. Jake Lusis (UCLA)
• Diana Shih (UCLA)